This content is for educational purposes only. Not medical advice. Always consult a licensed healthcare professional before using any peptides.

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Weight LossModerate RiskFDA-approved (Mounjaro/Zepbound)

Tirzepatide

The Dual Agonist

Tirzepatide is a dual GIP/GLP-1 receptor agonist that represents the next evolution in weight management peptides. By targeting two incretin pathways simultaneously, it delivers superior weight loss and metabolic improvements compared to single-agonist approaches. FDA-approved as Mounjaro (diabetes) and Zepbound (weight loss).

If You Take This

  • Superior weight loss vs single GLP-1 agonists
  • Up to 22% body weight reduction in trials
  • Dual incretin pathway activation
  • Improved insulin sensitivity
  • Significant reduction in waist circumference
  • Favorable lipid profile changes

Protocol

Dosing
Start at 2.5 mg once weekly for 4 weeks, titrate by 2.5 mg every 4 weeks up to 15 mg weekly.
Cycle Length
Ongoing — 6-12+ months with gradual dose titration.
Half-Life
5 days (once-weekly dosing)
Best Time
Same day each week, any time of day
Method
Subcutaneous injection

Stacks Well With

BPC-157 for GI side effects

Avoid With

Other GLP-1 or GIP agonistsSemaglutide (do not combine)

Side Effects

  • Nausea and vomiting (dose-dependent)
  • Diarrhea or constipation
  • Decreased appetite
  • Injection site reactions
  • Rare: pancreatitis, gallbladder issues

Where to Buy

PepStack Price Guarantee

We track prices across 5+ verified vendors so you don't have to. Every vendor is vetted for purity testing, third-party COAs, and shipping reliability.

Prices last verified: April 3, 2026

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For educational and informational purposes only. Not medical advice. Always consult a healthcare provider before starting any peptide protocol.