This content is for educational purposes only. Not medical advice. Always consult a licensed healthcare professional before using any peptides.

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Weight LossModerate RiskNot FDA-approved. Phase III clinical trials ongoing.

Tesofensine

The Triple Reuptake Inhibitor

Tesofensine is a serotonin-noradrenaline-dopamine reuptake inhibitor originally developed for Alzheimers and Parkinsons disease. During clinical trials, it was found to produce dramatic weight loss — up to 12.8% body weight in Phase II trials — making it one of the most potent weight loss compounds studied. It works by powerfully suppressing appetite and boosting metabolic rate.

If You Take This

  • Potent appetite suppression via triple reuptake inhibition
  • Up to 12.8% body weight loss in clinical trials
  • Increases metabolic rate and thermogenesis
  • Elevates mood and energy (dopamine/noradrenaline)
  • Reduces cravings and compulsive eating
  • Oral dosing for convenience

Protocol

Dosing
0.25-0.5mg oral daily. Start at 0.25mg and assess tolerance for 2 weeks before increasing. Do not exceed 0.5mg daily.
Cycle Length
8-12 weeks. Some protocols run 12-24 weeks under close monitoring. Blood pressure and heart rate should be tracked.
Half-Life
8-9 days
Best Time
Morning (to avoid insomnia)
Method
Oral (capsule)

Stacks Well With

5-Amino-1MQ (complementary mechanisms)BPC-157 for GI support

Avoid With

Other reuptake inhibitors (SSRIs, SNRIs) — risk of serotonin syndromeMAO inhibitorsStimulants (additive cardiovascular effects)

Side Effects

  • Elevated heart rate and blood pressure
  • Insomnia (dose in morning)
  • Dry mouth
  • Constipation
  • Anxiety or restlessness at higher doses
  • Headache

Where to Buy

Not Currently Available

Tesofensine is not currently available from our partner vendors. This may be due to regulatory status, limited supply, or vendor restrictions. Check back later as we regularly update our vendor listings.

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For educational and informational purposes only. Not medical advice. Always consult a healthcare provider before starting any peptide protocol.