This content is for educational purposes only. Not medical advice. Always consult a licensed healthcare professional before using any peptides.

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Weight LossModerate RiskFDA-approved (Ozempic/Wegovy)

Semaglutide

The GLP-1 King

Semaglutide is a GLP-1 receptor agonist originally developed for type 2 diabetes that has become the leading peptide for weight management. It reduces appetite by slowing gastric emptying and acting on brain satiety centers. FDA-approved as Ozempic (diabetes) and Wegovy (weight loss).

If You Take This

  • Significant appetite suppression
  • Average 15-20% body weight reduction
  • Improved glycemic control
  • Reduced cardiovascular risk markers
  • Decreased visceral fat
  • Lower systemic inflammation

Protocol

Dosing
Start at 0.25 mg once weekly for 4 weeks, titrate to 0.5 mg, then 1 mg, up to 2.4 mg weekly based on tolerance.
Cycle Length
Ongoing — typically 6-12+ months. Slow dose titration over first 16 weeks.
Half-Life
7 days (once-weekly dosing)
Best Time
Same day each week, any time of day
Method
Subcutaneous injection (abdomen, thigh, or upper arm)

Stacks Well With

Tirzepatide (alternative, not combined)BPC-157 for GI side effects

Avoid With

Other GLP-1 agonistsInsulin secretagogues without monitoring

Side Effects

  • Nausea (common, usually transient)
  • Constipation or diarrhea
  • Reduced appetite (therapeutic effect)
  • Injection site reactions
  • Rare: pancreatitis risk

Where to Buy

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Prices last verified: April 3, 2026

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For educational and informational purposes only. Not medical advice. Always consult a healthcare provider before starting any peptide protocol.