This content is for educational purposes only. Not medical advice. Always consult a licensed healthcare professional before using any peptides.

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Sexual HealthModerate RiskFDA-approved (Vyleesi) for premenopausal HSDD in women.

PT-141

The Desire Peptide

PT-141 (Bremelanotide) is a melanocortin receptor agonist that works centrally in the brain to stimulate sexual desire. Unlike PDE5 inhibitors that act on blood flow, PT-141 activates the MC3R and MC4R receptors in the hypothalamus, addressing the neurological component of arousal. FDA-approved as Vyleesi for female HSDD.

If You Take This

  • Activates central sexual desire pathways
  • Effective for both men and women
  • Works independently of blood flow mechanisms
  • Can be combined with PDE5 inhibitors
  • Rapid onset of action (30-60 minutes)
  • Addresses psychological component of arousal

Protocol

Dosing
1.75 mg subcutaneously, as needed, 45-60 minutes before anticipated activity. Maximum once every 24 hours, no more than 8 doses per month.
Cycle Length
As needed — not a daily protocol. Use sparingly to avoid receptor desensitization.
Half-Life
2.7 hours
Best Time
45-60 minutes before desired effect
Method
Subcutaneous injection or nasal spray

Stacks Well With

Avoid With

Uncontrolled hypertensionCardiovascular disease without clearance

Side Effects

  • Nausea (most common, dose-dependent)
  • Facial flushing
  • Headache
  • Transient blood pressure increase
  • Skin darkening at injection site with repeated use

Where to Buy

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Prices last verified: April 3, 2026

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99%+
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2-4 business days
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4.4
$30.00
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10mg
Purity
≥99%
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Core Peptides

4.8
$43.00
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10mg
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For educational and informational purposes only. Not medical advice. Always consult a healthcare provider before starting any peptide protocol.