This content is for educational purposes only. Not medical advice. Always consult a licensed healthcare professional before using any peptides.

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Sexual HealthModerate RiskNot FDA-approved. Used in clinical fertility research.

Kisspeptin

The Hormone Spark

Kisspeptin is the master regulator of the reproductive hormone cascade, stimulating GnRH neurons to initiate the release of LH and FSH, which in turn trigger testosterone and estrogen production. It sits at the very top of the hypothalamic-pituitary-gonadal (HPG) axis, making it a powerful tool for fertility support and natural hormone optimization without shutting down the axis.

If You Take This

  • Master regulator of reproductive hormone cascade
  • Stimulates natural GnRH → LH/FSH → testosterone/estrogen
  • Does not suppress the HPG axis (unlike exogenous hormones)
  • Used in fertility research for both men and women
  • Promotes natural hormone optimization
  • Potential for post-cycle therapy applications

Protocol

Dosing
1-10mcg/kg IV or subcutaneous (research dosing). Common protocol: 1mcg/kg subcutaneous. Dosing varies significantly by research context and clinical indication.
Cycle Length
Research protocols: single-dose or short 1-2 week courses. Not typically run in extended cycles. Used diagnostically and therapeutically in fertility clinics.
Half-Life
28 minutes (IV); longer for subcutaneous
Best Time
Morning (to mimic natural LH pulse)
Method
Subcutaneous or IV injection

Stacks Well With

HCG (fertility synergy)Clomiphene (post-cycle therapy)Zinc and vitamin D (hormone support)

Avoid With

Exogenous testosterone (counterproductive — suppresses GnRH response)GnRH analogs

Side Effects

  • Headache
  • Nausea
  • Hot flashes
  • Abdominal discomfort
  • Very limited long-term safety data for repeated use

Where to Buy

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Prices last verified: April 3, 2026

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For educational and informational purposes only. Not medical advice. Always consult a healthcare provider before starting any peptide protocol.